Andrew D Hamilton Selected Research

Farnesyltranstransferase (Farnesyltransferase)

10/2019	Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.
5/2011	Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.
9/2008	Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
9/2006	Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
8/2005	Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
6/2005	Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells.
12/2003	Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
12/2003	Farnesyltransferase inhibitors as anticancer agents: current status.
9/2003	Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf.
1/2003	Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines.

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Andrew D Hamilton Research Topics

Disease

26	Neoplasms (Cancer) 01/2021 - 03/2002
4	Carcinogenesis 10/2019 - 12/2003
3	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2017
3	Malaria 09/2008 - 08/2005
2	Breast Neoplasms (Breast Cancer) 05/2011 - 12/2003
2	Multiple Myeloma 05/2011 - 06/2005
2	Infections 04/2010 - 09/2002
1	Insulinoma 07/2022
1	Parkinson Disease (Parkinson's Disease) 04/2022
1	Amyloid Plaque 01/2017
1	Hypoxia (Hypoxemia) 04/2015
1	Acquired Immunodeficiency Syndrome (AIDS) 09/2013
1	AIDS-Related Opportunistic Infections 09/2013
1	Leukemia 05/2011
1	Chagas Disease (American Trypanosomiasis) 06/2009
1	Heart Diseases (Heart Disease) 04/2009
1	Inflammation (Inflammations) 04/2009
1	Parasitic Diseases (Parasitic Disease) 02/2009
1	Falciparum Malaria (Plasmodium falciparum Malaria) 02/2009
1	Atherosclerosis 09/2006
1	Starvation 06/2006
1	Neoplasm Metastasis (Metastasis) 05/2004
1	Melanoma (Melanoma, Malignant) 05/2004
1	Carcinoma (Carcinomatosis) 03/2004
1	African Trypanosomiasis (Nagana) 01/2004
1	Lung Neoplasms (Lung Cancer) 09/2003
1	Liver Neoplasms (Liver Cancer) 01/2003
1	Multiple Sclerosis 04/2002

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 04/2022 - 04/2002
10	Farnesyltranstransferase (Farnesyltransferase)IBA 10/2019 - 01/2003
3	geranylgeranyltransferase type-I (protein geranylgeranyltransferase)IBA 11/2007 - 03/2002
2	Amyloid (Amyloid Fibrils)IBA 01/2021 - 11/2017
2	Peptides (Polypeptides)IBA 01/2017 - 06/2005
2	EnzymesIBA 09/2013 - 03/2002
2	tipifarnib (R115777)IBA 05/2011 - 06/2005
2	Platelet-Derived Growth FactorIBA 06/2006 - 05/2004
2	PeptidomimeticsIBA 02/2006 - 03/2004
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2005 - 05/2004
1	Islet Amyloid PolypeptideIBA 07/2022
1	cucurbit(7)urilIBA 07/2022
1	SynucleinsIBA 04/2022
1	Antineoplastic Agents (Antineoplastics)IBA 10/2019
1	TransferasesIBA 10/2019
1	Amyloid beta-PeptidesIBA 11/2017
1	thymidylate synthase-dihydrofolate reductaseIBA 09/2013
1	Antiparasitic Agents (Antiparasitics)IBA 09/2013
1	Cell Surface ReceptorsIBA 07/2013
1	triciribineIBA 05/2011
1	ErbB Receptors (EGF Receptor)IBA 05/2011
1	Bcl-2-Like Protein 11IBA 03/2011
1	Apoptosis Regulatory ProteinsIBA 03/2011
1	calix(4)areneIBA 04/2010
1	ImidazolesIBA 06/2009
1	LanosterolIBA 06/2009
1	posaconazole FDA Link 06/2009
1	Phosphorylcholine (Phosphocholine)IBA 04/2009
1	C-Reactive ProteinIBA 04/2009
1	bcl-2 Homologous Antagonist-Killer Protein (bcl 2 Homologous Antagonist Killer Protein)IBA 04/2009
1	Molecular Probes (Molecular Probe)IBA 02/2009
1	ethylenediamine (ethylenediamine dihydroiodide)FDA Link 09/2008
1	Monomeric GTP-Binding ProteinsIBA 11/2007
1	Glycogen Synthase Kinase 3 betaIBA 04/2007
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2006
1	PorphyrinsIBA 12/2005
1	Calixarenes (Calixarene)IBA 12/2005
1	GFB-204IBA 07/2005
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 07/2005
1	Paclitaxel (Taxol)FDA LinkGeneric 06/2005
1	Docetaxel (Taxotere)FDA Link 06/2005
1	Phosphotransferases (Kinase)IBA 07/2004
1	API 2IBA 07/2004
1	API-2 nucleosideIBA 07/2004
1	GFA 116IBA 05/2004
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 03/2004
1	Transcription Factors (Transcription Factor)IBA 03/2004
1	4-cyanobenzoic acidIBA 03/2004
1	GGTI-2154IBA 12/2003
1	Oncogene Proteins (Oncogene Protein)IBA 12/2003
1	FTI 276IBA 09/2003
1	CarcinogensIBA 09/2003
1	L 778,123IBA 09/2003
1	FTI 277IBA 01/2003
1	1,5- bis(2- methoxy- 4- nitro- 5- sulfophenyl)- 3- ((phenylamino)carbonyl)formazanIBA 09/2002
1	Antiviral Agents (Antivirals)IBA 09/2002
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 04/2002
1	Dimethylallyltranstransferase (Dimethylallyltransferase)IBA 04/2002
1	Small Molecule LibrariesIBA 03/2002
1	ras ProteinsIBA 03/2002

Therapy/Procedure

11	Therapeutics 10/2019 - 01/2004
1	Aftercare (After-Treatment) 12/2003
1	Chemoprevention 09/2003